Can Integrative Therapies Reduce Pain and Improve Quality of Life in Women with Endometriosis? A Systematic Review

Abstract

Introduction: Endometriosis is a chronic inflammatory condition affecting millions of women worldwide, often causing severe pain and reduced quality of life. Conventional treatments have limitations, leading to growing interest in integrative therapies. This systematic review aims to evaluate the effectiveness of these therapies in reducing pain and improving the quality of life in women with endometriosis.   

Methods: A systematic literature search was conducted following PRISMA 2020 guidelines across PubMed, ScienceDirect, and Cochrane databases through August 2025. Studies involving women with endometriosis receiving integrative therapies (e.g., psychological interventions, physical therapy, yoga, electrotherapy, dietary modifications) were included. Data on pain scores and quality of life were extracted and synthesized qualitatively.   

Results: Out of 1,477 identified records, 17 studies met the inclusion criteria. The evidence suggests that various integrative therapies are beneficial. Cognitive Behavioral Therapy (CBT) and relaxation techniques consistently improved emotional well-being and pain coping. Physical therapy demonstrated significant reductions in endometriosis-related chronic pain and enhancements in quality of life. Electrotherapies, besides reducing pain, additionally improve sexual function. Lastly, nutritional therapy showed positive effects on pain control and gastrointestinal symptoms.   

Conclusion: Integrative therapies represent a valuable complementary approach for managing endometriosis-related pain and improving quality of life. The choice of adjunctive therapy should be guided by the patient's accompanying symptoms and individual clinical needs.